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What is Sickle Cell An 24 about?

Sickle cell anemia is caused by a mutation in the β globin gene leading to the formation of HbS, which can polymerize and deform red blood cells into a sickle shape. The disease has a carrier rate of 8% in the USA and up to 30% in Africa, providing some protection against malaria. Clinical features include anemia, painful vaso-occlusive crises, pulmonary complications, and increased susceptibility to infections, with diagnosis based on hemoglobin levels and blood cell morphology.

Author

Waqar Ahmad Khan

Language

EN