About this Medicine article
Rapid T ~1~ mapping of mouse myocardium with saturation recovery look‐locker method by Wen Li; Mark Griswold; Xin Yu is a Medicine article available to read on EtoBox.
## Abstract Dynamic contrast‐enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look‐Locker method was developed and validated for fast cardiac __T__~1~ mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal resolution (∼3 min) can be achieved at a high spatial resolution (195 × 390 μm2) in mouse heart without the aid of parallel imaging or echo‐planar imaging. Validation studies were performed both in vitro on a phantom and in vivo on C57BL/6 mice (__n__ = 6). Our results showed a strong agreement between __T__~1~ measured by saturation recovery Look‐Locker and by the standard saturation recovery method in vitro or inversion recovery Look‐Locker in vivo. The utility of saturation recovery Look‐Locker in dynamic contrast‐enhanced MRI studies was demonstrated in manganese‐enhanced MRI experiments in mice. Our results suggest that saturation recovery Look‐Locker can provide rapid and accurate cardiac __T__~1~ mapping for studies using small animal models. Magn Reson Med, 2010. © 201
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- Author
- Wen Li; Mark Griswold; Xin Yu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)