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Can I read Combined Action of Fluorouracil and Two Mutant Genes on Limb Development in the Mouse on EtoBox?
Combined Action of Fluorouracil and Two Mutant Genes on Limb Development in the Mouse by C. P. Dagg is a Environmental Science article available to read on EtoBox.
What is Combined Action of Fluorouracil and Two Mutant Genes on Limb Development in the Mouse about?
The influence of a teratogen on the penetrance and expressivity of two mutant genes that affect limb development in mice was investigated. A low dose of the teratogen, 5-fluorouracil, produced preaxially hyperphalangous hind feet in a large proportion of wild type fetuses when injected at ten days of development. A high dose increased the frequency of hyperphalangy, caused tibial hemimelia in many hyperphalangous fetuses, and produced cleft palate and vertebral deformities. The mutations, luxoid and luxate, are autosomal semidominant genes that induce preaxially polydactylous hind feet in heterozygotes and tibial hemimelia in homozygotes. Other pleiotropic effects of luxoid in homozygotes are polydactylous forefeet, kinked tails, agenesis of the patella, and infertility in males. In luxate homozygotes the forefeet, tail and patella are normal but the fabella medialis, a sesamoid bone of the knee, is absent. Wild type females were mated to heterozygous luxoid or luxate males and injected with the low dose of fluorouracil. Some of the treated offspring were allowed to be delivered and were subsequently mated to determine their genotypes. Tibia1 hemimelia was found in some heterozygou
Who reads Combined Action of Fluorouracil and Two Mutant Genes on Limb Development in the Mouse?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- C. P. Dagg
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)
- Published
- 1967
- Language
- EN
- Field
- Environmental Science (Life Sciences)