Opening book details…
Can I read Development of Nicotinic Receptor Clusters and Innervation Accompanying the Change in Muscle Phenotype in the Mouse Esophagus on EtoBox?
Development of Nicotinic Receptor Clusters and Innervation Accompanying the Change in Muscle Phenotype in the Mouse Esophagus by Sang, Q.; Young, H.M. is a Neuroscience article available to read on EtoBox.
What is Development of Nicotinic Receptor Clusters and Innervation Accompanying the Change in Muscle Phenotype in the Mouse Esophagus about?
During development, the external muscle of the mouse esophagus undergoes a transdifferentiation from smooth to striated muscle (Patapoutian et al. [1995] Science 270:1818-1821). We now report on the development of the innervation accompanying the change in phenotype of the external muscle of the mouse esophagus. The phenotype of the muscle was monitored by using light and electron microscopy. Nicotinic acetylcholine receptors were localised by using a fluorescence conjugate of a-bungarotoxin, and neural elements were localised by using antisera to synaptophysin (a synaptic vesicle protein that was used to label all nerve terminals), the vesicular acetylcholine transporter (VAChT), calcitonin gene-related peptide (CGRP), nitric oxide synthase (NOS), and vasoactive intestinal peptide (VIP). CGRP and VAChT were co-localised in the terminals of vagal motoneurons that innervate the external muscle, and NOS and VIP were co-localised in intrinsic (enteric) neurons, which provide some terminals that are associated with motor endplates. Cells exhibiting striations were first observed in the outer layers of the most rostral regions of the esophagus of embryonic day 15 (E15) mice. Clusters of
Who reads Development of Nicotinic Receptor Clusters and Innervation Accompanying the Change in Muscle Phenotype in the Mouse Esophagus?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Sang, Q.; Young, H.M.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)
- Published
- 1997
- Language
- EN
- Field
- Neuroscience (Life Sciences)