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Can I read DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1–NFATc2 fusion from Ewing sarcoma on EtoBox?
DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1–NFATc2 fusion from Ewing sarcoma by Christian Koelsche; Mark Kriegsmann; Felix K. F. Kommoss; Damian Stichel; Katharina Kriegsmann; Christian Vokuhl; Thomas G. P. Grünewald; Laura Romero-Pérez; Thomas Kirchner; Enrique de Alava; Juan Diaz-Martin; Wolfgang Hartmann; Daniel Baumhoer; Cristina R. Antonescu; Karoly Szuhai; Uta Flucke; Uta Dirksen; Stefan M. Pfister; David T. W. Jones; Gunhild Mechtersheimer; Andreas von Deimling is a Medicine article available to read on EtoBox.
What is DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1–NFATc2 fusion from Ewing sarcoma about?
## Purpose: Recent studies revealed divergent gene expression patterns in ewing sarcoma (ews) with canonical ewsr1-ets gene fusions and undifferentiated round cell sarcomas (urcs) with ewsr1 rearrangements fused to the non-ets gene nfatc2. thus, the question arises whether the latter tumors really belong to ews. ## Methods: We collected five cases matching the group of urcs with ewsr1-nfatc2 fusion and performed dna methylation and copy number profiling. results were compared to methylation data of 30 ews with various ewsr1-ets fusions and one ews with fus-erg fusion, 16 urcs with cic rearrangement and 10 urcs with bcor alteration and a total of 81 ewsr1-associated soft tissue sarcomas including 7 angiomatoid fibrous histiocytomas, 7 clear cell sarcomas of the soft tissue, 28 desmoplastic small round cell tumors, 10 extraskeletal myxoid chondrosarcomas and 29 myxoid liposarcomas. ## Results: Unsupervised hierarchical clustering and t-distributed stochastic neighbor embedding analysis of dna methylation data revealed a homogeneous methylation cluster for urcs with ewsr1-nfatc2 fusion, which clearly segregated from ews and the other subtypes. copy number profiles of ewsr1-nfatc2 case
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- Author
- Christian Koelsche; Mark Kriegsmann; Felix K. F. Kommoss; Damian Stichel; Katharina Kriegsmann; Christian Vokuhl; Thomas G. P. Grünewald; Laura Romero-Pérez; Thomas Kirchner; Enrique de Alava; Juan Diaz-Martin; Wolfgang Hartmann; Daniel Baumhoer; Cristina R. Antonescu; Karoly Szuhai; Uta Flucke; Uta Dirksen; Stefan M. Pfister; David T. W. Jones; Gunhild Mechtersheimer; Andreas von Deimling
- Publisher
- Springer Science and Business Media LLC
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)