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Can I read Positron Emission Tomography-Guided, Focal-Dose Escalation Using Intensity-Modulated Radiotherapy for Head and Neck Cancer on EtoBox?
Positron Emission Tomography-Guided, Focal-Dose Escalation Using Intensity-Modulated Radiotherapy for Head and Neck Cancer by Indira Madani; Wim Duthoy; Cristina Derie; Werner De Gersem; Tom Boterberg; Micky Saerens; Filip Jacobs; Vincent Grégoire; Max Lonneux; Luc Vakaet; Barbara Vanderstraeten; Wouter Bauters; Katrien Bonte; Hubert Thierens; Wilfried De Neve is a Medicine article available to read on EtoBox.
What is Positron Emission Tomography-Guided, Focal-Dose Escalation Using Intensity-Modulated Radiotherapy for Head and Neck Cancer about?
Purpose: To assess the feasibility of intensity-modulated radiotherapy (IMRT) using positron emission tomography (PET)-guided dose escalation, and to determine the maximum tolerated dose in head and neck cancer. Methods and Materials: A Phase I clinical trial was designed to escalate the dose limited to the [ 18 -F]fluoro-2-deoxy-D-glucose positron emission tomography ( 18 F-FDG-PET)-delineated subvolume within the gross tumor volume. Positron emission tomography scanning was performed in the treatment position. Intensity-modulated radiotherapy with an upfront simultaneously integrated boost was employed. Two dose levels were planned: 25 Gy (level I) and 30 Gy (level II), delivered in 10 fractions. Standard IMRT was applied for the remaining 22 fractions of 2.16 Gy. Results: Between 2003 and 2005, 41 patients were enrolled, with 23 at dose level I, and 18 at dose level II; 39 patients completed the planned therapy. The median follow-up for surviving patients was 14 months. Two cases of dose-limiting toxicity occurred at dose level I (Grade 4 dermitis and Grade 4 dysphagia). One treatmentrelated death at dose level II halted the study. Complete response was observed in 18 of 21 (86%
Who reads Positron Emission Tomography-Guided, Focal-Dose Escalation Using Intensity-Modulated Radiotherapy for Head and Neck Cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Indira Madani; Wim Duthoy; Cristina Derie; Werner De Gersem; Tom Boterberg; Micky Saerens; Filip Jacobs; Vincent Grégoire; Max Lonneux; Luc Vakaet; Barbara Vanderstraeten; Wouter Bauters; Katrien Bonte; Hubert Thierens; Wilfried De Neve
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)