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Dual-responsive Drug Release and Fluorescence Imaging Based on Disulfide-pillar[4]arene Aggregate in Cancer Cells by Mian Tang; Yao-Hua Liu; Xin-Miao Xu; Ying-Ming Zhang; Yu Liu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Dual-responsive Drug Release and Fluorescence Imaging Based on Disulfide-pillar[4]arene Aggregate in Cancer Cells about?

The construction of multistimuli-responsive nanoaggregate has become one of the increasingly significant research topics in supramolecular chemistry. We herein reported the pH- and glutathione dual-responsive supramolecular assemblies fabricated by the disulfide-containing pillar[4]arene and tetraphenylethylene derivatives possessing different alkyl chains in length. Morphological characterization experiments showed the binary supramolecular assemblies formed well-defined nanoparticles, which could facilitate their endocytosis in cells. More remarkably, due to the compact nanostructures and the existence of acidifiable carboxyl group and bioreducible disulfide linkage in pillar[4]arene, the obtained nanoaggregates presented high drug-loading efficiency and sustained drug release behaviors, as well as the targeted fluorescence imaging ability in cancer cells. Thus, it can be envisioned that such microenvironment-adaptable supramolecular nanoassemblies featuring dual stimuli-responsiveness and fluorescence-imaging abilities may be developed as more appealing nanosystems for the therapy of refractory disease.

Who reads Dual-responsive Drug Release and Fluorescence Imaging Based on Disulfide-pillar[4]arene Aggregate in Cancer Cells?

Author

Mian Tang; Yao-Hua Liu; Xin-Miao Xu; Ying-Ming Zhang; Yu Liu

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)