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Potent Antitumor Activity After Systemic Delivery of a Doubly Fusogenic Oncolytic Herpes Simplex Virus Against Metastatic Prostate Cancer by Mikihito Nakamori; Xinping Fu; Curtis A. Pettaway; Xiaoliu Zhang is a Medicine article available to read on EtoBox.

What is Potent Antitumor Activity After Systemic Delivery of a Doubly Fusogenic Oncolytic Herpes Simplex Virus Against Metastatic Prostate Cancer about?

## Abstract ## BACKGROUND Although conventional radiation therapy and surgery are potentially curative treatments for organ‐confined prostate cancer, there are few effective treatments for metastatic disease. Oncolytic viruses have shown considerable promise for the treatment of solid tumors including prostate cancer. We recently demonstrated that incorporation of a cell membrane fusion capability into an oncolytic herpes simplex virus (HSV) can significantly increase the antitumor potency of the virus. ## METHODS We used a mouse model of primary and metastatic human prostate cancer established from PC‐3M‐Pro4 to evaluate three different types of oncolytic HSVs: non‐fusogenic Baco‐1, singly fusogenic Synco‐2, and doubly fusogenic Synco‐2D. ## RESULTS Our results show that Synco‐2D has greater oncolytic activity than either Baco‐1 or Synco‐2 virus. Against lung metastases of human prostate cancer xenografts, intravenous administration of Synco‐2D had produced a significant reduction of tumor nodules by day 40 post‐inoculation as compared with Synco‐2 (__P__ < 0.05), Baco‐1 (__P__ < 0.01), and PBS control (__P__ < 0.01). ## CONCLUSIONS We conclude that the doubly fusogenic Synco‐2D i

Who reads Potent Antitumor Activity After Systemic Delivery of a Doubly Fusogenic Oncolytic Herpes Simplex Virus Against Metastatic Prostate Cancer?

Author

Mikihito Nakamori; Xinping Fu; Curtis A. Pettaway; Xiaoliu Zhang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2004

Language

EN

Field

Medicine (Health Sciences)