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Can I read Production of islet cell antibodies from Epstein-Barr virus-transformed peripheral blood lymphocytes in Type 1 (insulin-dependent) diabetic patients on EtoBox?
Production of islet cell antibodies from Epstein-Barr virus-transformed peripheral blood lymphocytes in Type 1 (insulin-dependent) diabetic patients by Y. Yamaguchi; N. Chikuba; T. Nakanishi; H. Yamamoto; S. Okuno; Y. Maeda; M. Akashi; S. Akazawa; S. Nagataki is a Medicine article available to read on EtoBox.
What is Production of islet cell antibodies from Epstein-Barr virus-transformed peripheral blood lymphocytes in Type 1 (insulin-dependent) diabetic patients about?
Islet cell antibodies are usually detected in the sera of almost all Type i (insulin-dependent) diabetic patients within several months after onset of the disease. The antibodies then disappear quite early during the course of the disease. The present study was undertaken to detect islet cell antibody-producing clones in peripheral blood lymphocytes of Type 1 diabetic patients whose islet cell antibodies could not be detected in sera. Epstein-B arr virus-transformed lymphocytes were employed to enhance the production of antibodies and to detect the clones from peripheral blood lymphocytes. Peripheral blood lymphocytes were obtained from 40 islet cell antibody-negative Type 1 diabetic patients, 10 antibody-positive Type 1 diabetic patients, 30 Type 2 (non-insulin-dependent) diabetic patients and 40 normal control subjects. Epstein-Barr virus-transformed lymphocytes were cultured for 4 weeks and the culture supernatants were used for assay of islet cell antibodies. Islet cell antibody assays were performed by immunohistochemical methods using peroxidase-labelled protein A for IgG antibodies, peroxidase-labelled anti-human IgM antibodies for IgM anti-bodies and fresh frozen human panc
Who reads Production of islet cell antibodies from Epstein-Barr virus-transformed peripheral blood lymphocytes in Type 1 (insulin-dependent) diabetic patients?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Y. Yamaguchi; N. Chikuba; T. Nakanishi; H. Yamamoto; S. Okuno; Y. Maeda; M. Akashi; S. Akazawa; S. Nagataki
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0012-186X)
- Published
- 1991
- Language
- EN
- Field
- Medicine (Health Sciences)