Opening book details…
Can I read Acute and 28-Day Repeated Dose Oral Toxicity Study of Caraway Oil in Rats on EtoBox?
Acute and 28-Day Repeated Dose Oral Toxicity Study of Caraway Oil in Rats by Sandip T. Auti; Yogesh A. Kulkarni is a Medicine article available to read on EtoBox.
What is Acute and 28-Day Repeated Dose Oral Toxicity Study of Caraway Oil in Rats about?
## Abstract ## Background Caraway oil (CO) obtained from the fruits of __Carum carvi__ L. (Apiaceae) is used in traditional systems of medicine for various diseases. The present study was designed to evaluate the safety profile of CO by acute and repeated dose oral toxicity as per the Organisation for Economic Co-operation and Development guidelines 423 and 407, respectively. ## Methods In an acute toxicity study, a single dose of CO (300 and 2000 mg/kg) was given to female Wistar rats, and the animals were observed for signs of behavioral alterations, morbidity and mortality for 14 days. Repeated dose toxicity was performed at doses of 50, 100 and 200 mg/kg for 28 days in Wistar rats. The effects of CO on food and water intake, body weight, relative organ weight, clinical biochemistry, hematological parameters and urine parameters were studied. Gross necropsy and histopathology of vital organs were carried out. ## Results A single oral dose at 300 mg/kg CO did not show any signs of toxicity and mortality, while a dose of 2000 mg/kg showed signs of mortality in one animal and some signs of toxicity in another two animals. In the repeated dose toxicity study, CO at selected dose lev
Who reads Acute and 28-Day Repeated Dose Oral Toxicity Study of Caraway Oil in Rats?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sandip T. Auti; Yogesh A. Kulkarni
- Publisher
- Walter de Gruyter GmbH
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)