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Development and Experimental Evaluation of Some Silver Nanoparticles with Antimicrobial Potential by Bruno Ștefan Velescu; Marina Ionela Ilie; Anca Ioana Amzăr; Raluca Elisabeta Lupașcu; Ilinca Mihaela Marandiuc; Miruna-Maria Apetroaei; Andreea Letiția Arsene; Emilian Ionuț Blejan; Octvian Alexandru Nedea; Toma Fistos; Radu Claudiu Fierăscu; Florica Bărbuceanu; Cristina Țoca; Irina Fierăscu; Denisa Ioana Udeanu; Manuela Ghica; Doina Drăgănescu; Pavel Călin Cobelschi is a Engineering article available to read on EtoBox.

What is Development and Experimental Evaluation of Some Silver Nanoparticles with Antimicrobial Potential about?

By adjusting the synthesis process, silver nanoparticles (AgNp) of various shapes, sizes, and structures can be obtained, all of which have a substantial impact on the biological effect, notably, the regulation of antibacterial activity in the present circumstances of growing bacterial resistance. Due to their relatively small size, nanoparticles may be disseminated evenly throughout the body of the experimental animal, even at low doses, and exert more potent antibacterial activities. Our research was centered on the synthesis, production, and biological evaluation of antibacterial silver nanoparticles. Using the Turkevich method, we were able to effectively synthesize and characterize nanoscale silver particles, with an average crystallite size of 9.49 nm. We examined their acute toxicity and pharmacokinetic characteristics in rats after administering a single dosage. In addition, we evaluated the biological effect of topical AgNp suspension on the progression of burn-type lesions in the experimental animals. The pharmacokinetic profile demonstrated that the plasma concentration of silver nanoparticles, as well as their clearance rate, and dispersion throughout the body, are sign

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Author

Bruno Ștefan Velescu; Marina Ionela Ilie; Anca Ioana Amzăr; Raluca Elisabeta Lupașcu; Ilinca Mihaela Marandiuc; Miruna-Maria Apetroaei; Andreea Letiția Arsene; Emilian Ionuț Blejan; Octvian Alexandru Nedea; Toma Fistos; Radu Claudiu Fierăscu; Florica Bărbuceanu; Cristina Țoca; Irina Fierăscu; Denisa Ioana Udeanu; Manuela Ghica; Doina Drăgănescu; Pavel Călin Cobelschi

Publisher

MDPI AG

Published

2023

Language

EN

Field

Engineering (Physical Sciences)