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Concentrations and Effects of Buspirone Are Considerably Reduced by Rifampicin by T. S. Lamberg; K. T. Kivistö; P. J. Neuvonen is a Medicine article available to read on EtoBox.

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__Aims__ The effects of rifampicin on the pharmacokinetics and pharmacodynamics of buspirone, a non‐benzodiazepine anxiolytic agent, were investigated. __Methods__ In a randomized, placebo‐controlled cross‐over study with two phases, 10 young healthy volunteers took either 600 mg rifampicin or matched placebo once daily for 5 days. On day 6, 30 mg buspirone was administered orally. Plasma buspirone concentrations and effects of buspirone were measured up to 10 h. __Results__ The total area under the plasma buspirone concentration‐time curve after rifampicin was 10.4% (95% CI, 6.3–14.5%) of that after placebo (1.64±0.35 ng ml^−1^ h __vs__ 22.0±15.1 ng ml^−1^ h (mean±s.d.); __P__<0.01). Rifampicin decreased the peak plasma concentration of buspirone from 6.6±3.7 ng ml^−1^ to 0.84±0.23 ng ml^−1^ (__P__<0.01) and the half‐life from 2.8±0.7 h to 1.3±0.5 h (__P__<0.01). A significant (__P__<0.05) reduction in the effects of buspirone was observed in three of the six psychomotor tests employed (postural sway test with eyes closed, subjective drowsiness and overall drug effect) after rifampicin pretreatment. __Conclusions__ The strong interaction between rifampicin and buspirone is probabl

Who reads Concentrations and Effects of Buspirone Are Considerably Reduced by Rifampicin?

Author

T. S. Lamberg; K. T. Kivistö; P. J. Neuvonen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)

Published

1998

Language

EN

Field

Medicine (Health Sciences)