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Can I read Unraveling the Diversity and Functions of Tissue-resident Plasma Cells on EtoBox?
Unraveling the Diversity and Functions of Tissue-resident Plasma Cells by Julie Tellier; Ilariya Tarasova; Junli Nie; Christopher S. Smillie; Pasquale L. Fedele; Wang H. J. Cao; Joanna R. Groom; Gabrielle T. Belz; Deepta Bhattacharya; Gordon K. Smyth; Stephen L. Nutt is a Immunology and Microbiology article available to read on EtoBox.
What is Unraveling the Diversity and Functions of Tissue-resident Plasma Cells about?
Antibody-secreting plasma cells (PCs) are generated in secondary lymphoid organs but are reported to reside in an emerging range of anatomical sites. Analysis of the transcriptome of different tissue-resident (Tr)PC populations revealed that they each have their own transcriptional signature indicative of functional adaptation to the host tissue environment. In contrast to expectation, all TrPCs were extremely long-lived, regardless of their organ of residence, with longevity influenced by intrinsic factors like the immunoglobulin isotype. Analysis at single-cell resolution revealed that the bone marrow is unique in housing a compendium of PCs generated all over the body that retain aspects of the transcriptional program indicative of their tissue of origin. This study reveals that extreme longevity is an intrinsic property of TrPCs whose transcriptome is imprinted by signals received both at the site of induction and within the tissue of residence.
Who reads Unraveling the Diversity and Functions of Tissue-resident Plasma Cells?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Julie Tellier; Ilariya Tarasova; Junli Nie; Christopher S. Smillie; Pasquale L. Fedele; Wang H. J. Cao; Joanna R. Groom; Gabrielle T. Belz; Deepta Bhattacharya; Gordon K. Smyth; Stephen L. Nutt
- Publisher
- Springer Science and Business Media LLC
- Published
- 2024
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)