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Can I read Increasing genetic distance to HIV-1 subtype B and F1 consensus sequences in the Brazilian epidemic: A challenge for vaccine strategies based on central immunogens? on EtoBox?
Increasing genetic distance to HIV-1 subtype B and F1 consensus sequences in the Brazilian epidemic: A challenge for vaccine strategies based on central immunogens? by Gonzalo Bello; Monick L. Guimarães; Saada L. Chequer-Fernandez; Walter A. Eyer-Silva; José C. Couto-Fernandez; Sylvia L.M. Teixeira; Mariza G. Morgado is a Medicine article available to read on EtoBox.
What is Increasing genetic distance to HIV-1 subtype B and F1 consensus sequences in the Brazilian epidemic: A challenge for vaccine strategies based on central immunogens? about?
It has been postulated that the non-synonymous divergence (distance to the subtype consensus sequence) observed in several HIV-1 subtype populations during 1990s attained the maximum limit that is compatible with viral fitness or survival, at least in the V3 env gene domain. To test this hypothesis, 145 subtype B and 64 subtype F env V3 sequences isolated from Brazilian HIV-1 positive patients between 1989 and 2004 were analyzed. HIV-1 env V3 sequences were grouped by year of collection and the mean intra-subtype diversity and divergence were examined at synonymous, non-synonymous, and amino acid level. The analyses clearly show that the mean intra-subtype divergence constantly increases in both subtype populations in the last 15 years, and more importantly, this trend was not only driven by a significant increase of the synonymous distance but also by a significant increase of the non-synonymous and amino acid distances between Brazilian circulating viruses and subtype consensus sequences. These results clearly disagree with the notion that the non-synonymous distance to the HIV-1 subtype consensus observed at population level had already attained the maximum limit, and suggest th
Who reads Increasing genetic distance to HIV-1 subtype B and F1 consensus sequences in the Brazilian epidemic: A challenge for vaccine strategies based on central immunogens??
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gonzalo Bello; Monick L. Guimarães; Saada L. Chequer-Fernandez; Walter A. Eyer-Silva; José C. Couto-Fernandez; Sylvia L.M. Teixeira; Mariza G. Morgado
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-1348)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)