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Construction of ceRNA Network Based on TCGA and UCSC Xena Official Website to Provide Certain Help for Immunotherapy of Thyroid Cancer. by Junwei Du; Xinguang Qiu; Guoquan Li; Yangsen Li is a scholarly article available to read on EtoBox.

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## Abstract Background: Thyroid cancer is the most common endocrine tumor, and papillary thyroid carcinoma is the most common. Commonly used treatment methods include surgery and radiotherapy. As an emerging treatment option in recent years, immunotherapy has played an essential role in the treatment of many tumors, but there are few studies in thyroid cancer. Method: We first downloaded the mRNA and lncRNA data of thyroid cancer patients from the TCGA official website https://portal.gdc.cancer.gov/, and downloaded the miRNA of thyroid cancer patients from UCSC Xena https://xenabrowser.net/ data. Through the tumor microenvironment's immune score, tumor samples are divided into cold tumors and hot tumors. We obtained the differential genes of DEGs, lncRNA and miRNA, and jointly constructed a ceRNA network through differential analysis of the mRNA data of cold and hot tumours. Results: We first assessed the immune infiltration of the tumor microenvironment of patients with thyroid cancer, and divided the samples into cold tumors and hot tumors based on the immune score. A total of 568 up-regulated DEGs and 412 down-regulated DEGs were screened by analysing the difference between hot

Author

Junwei Du; Xinguang Qiu; Guoquan Li; Yangsen Li

Publisher

Research Square Platform LLC

Published

2021

Language

EN