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Can I read Effect of Treatment Intensification on Glycemic Control in Patients with Subcontrolled Type 2 Diabetes Who Failed on Two Oral Antidiabetic Agents on EtoBox?
Effect of Treatment Intensification on Glycemic Control in Patients with Subcontrolled Type 2 Diabetes Who Failed on Two Oral Antidiabetic Agents by Tan, Malinda S. (author);Kim, Kibum (author);Olsen, Cody J. (author);Brixner, Diana I. (author) is a Medicine article available to read on EtoBox.
What is Effect of Treatment Intensification on Glycemic Control in Patients with Subcontrolled Type 2 Diabetes Who Failed on Two Oral Antidiabetic Agents about?
Aims Treatment intensification (TI) may help patients with type 2 diabetes mellitus (T2DM) achieve target hemoglobin A1c (A1c) < 7.0%. This study aimed to measure the influence of TI on A1c outcome in patients who insufficiently responded to two classes of oral antidiabetic drugs (2OADs). Materials and methods A retrospective observational study of patients with T2DM was performed using health plan claims and A1c records accrued between January 2010 and March 2017. The study population had an A1c ≥ 7.0% (baseline A1c) after treatment with 2OADs for one year. Patients who had TI with a third-class antidiabetic agent, including basal/biphasic insulin, glucagon-like peptide-1 receptor agonists (GLP-1RA), or OAD, within 365 days after baseline A1c were included. Patients who did not receive TI (NTI) within one year from the suboptimal A1c control were matched with TI patients using a propensity score approach. The odds ratio of achieving an A1c < 9.0% and < 7.0% for TI vs. NTI were calculated by logistic regressions. Results A1c values of 401 TI − NTI matched pairs were analyzed. TI patients achieved a significantly lower follow-up A1c than NTI patients (7.79% ± 1.45 vs. 8.02% ± 1.67,
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- Author
- Tan, Malinda S. (author);Kim, Kibum (author);Olsen, Cody J. (author);Brixner, Diana I. (author)
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)