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Local and Distant Recurrence After Conservative Management of “Very Low-risk” Breast Cancer Are Dependent Events: a 10-Year Follow-up by Didier Cowen; Jocelyne Jacquemier; Gilles Houvenaeghel; Patrice Viens; Brigitte Puig; Valerie-Jeanne Bardou; Michel Resbeut; Dominique Maraninchi is a Medicine article available to read on EtoBox.

What is Local and Distant Recurrence After Conservative Management of “Very Low-risk” Breast Cancer Are Dependent Events: a 10-Year Follow-up about?

Purpose: To determine the risk factors associated with recurrence after breast-conserving treatments, and the relationship between occurrence of a local recurrence and subsequent distant metastases. Methods and Materials: Among the 3697 patients with primary breast cancer treated at Institut Paoli-Calmettes Cancer Center, Marseille, between 1980 and 1995, we retrospectively analyzed 756 patients who had been treated with conservative surgery with uninvolved margins of excision, were node-negative, and had received uniform radiotherapy and no chemotherapy. One third of the patients received hormonal therapy via tamoxifen or surgical castration. The endpoints considered were local failures and distant metastases. All tumors were reviewed by our pathologists. The median follow-up for the 700 survivors was 62 months. Results: In the multivariate analysis, histological multifocality (p ‫؍‬ 0.0076), peritumoral vessel invasion (p ‫؍‬ 0.0215), and young age (p ‫؍‬ 0.0245) were associated with an increased risk of local recurrences, whereas tumor size (p ‫؍‬ 0.0013), young age (p ‫؍‬ 0.003), and histological multifocality (p ‫؍‬ 0.0414) were associated with an increased risk of distant met

Who reads Local and Distant Recurrence After Conservative Management of “Very Low-risk” Breast Cancer Are Dependent Events: a 10-Year Follow-up?

Author

Didier Cowen; Jocelyne Jacquemier; Gilles Houvenaeghel; Patrice Viens; Brigitte Puig; Valerie-Jeanne Bardou; Michel Resbeut; Dominique Maraninchi

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1998

Language

EN

Field

Medicine (Health Sciences)