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Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether by Xia, Yingchun (author);Song, Ziyuan (author);Tan, Zhengzhong (author);Xue, Tianrui (author);Wei, Shiqi (author);Zhu, Lingyang (author);Yang, Yingfeng (author);Fu, Hailin (author);Jiang, Yunjiang (author);Lin, Yao (author);Lu, Yanbing (author);Ferguson, Andrew L. (author);Cheng, Jianjun (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether about?
## Abstract The recent advances in accelerated polymerization of N-carboxyanhydrides (NCAs) enriched the toolbox to prepare well-defined polypeptide materials. Herein we report the use of crown ether (CE) to catalyze the polymerization of NCA initiated by conventional primary amine initiators in solvents with low polarity and low hydrogen-bonding ability. The cyclic structure of the CE played a crucial role in the catalysis, with 18-crown-6 enabling the fastest polymerization kinetics. The fast polymerization kinetics outpaced common side reactions, enabling the preparation of well-defined polypeptides using an α-helical macroinitiator. Experimental results as well as the simulation methods suggested that CE changed the binding geometry between NCA and propagating amino chain-end, which promoted the molecular interactions and lowered the activation energy for ring-opening reactions of NCAs. This work not only provides an efficient strategy to prepare well-defined polypeptides with functionalized C-termini, but also guides the design of catalysts for NCA polymerization.
Who reads Accelerated polymerization of N-carboxyanhydrides catalyzed by crown ether?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Xia, Yingchun (author);Song, Ziyuan (author);Tan, Zhengzhong (author);Xue, Tianrui (author);Wei, Shiqi (author);Zhu, Lingyang (author);Yang, Yingfeng (author);Fu, Hailin (author);Jiang, Yunjiang (author);Lin, Yao (author);Lu, Yanbing (author);Ferguson, Andrew L. (author);Cheng, Jianjun (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)