Opening book details…
Can I read Inhibition of Lysyl Oxidase‐like 2 Overcomes Adhesion‐dependent Drug Resistance in the Collagen‐enriched Liver Cancer Microenvironment on EtoBox?
Inhibition of Lysyl Oxidase‐like 2 Overcomes Adhesion‐dependent Drug Resistance in the Collagen‐enriched Liver Cancer Microenvironment by Lanqi Gong; Yu Zhang; Yuma Yang; Qian Yan; Jifeng Ren; Jie Luo; Yuen Chak Tiu; Xiaona Fang; Beilei Liu; Raymond Hiu Wai Lam; Ka‐On Lam; Anne Wing‐Mui Lee; Xin‐Yuan Guan is a Medicine article available to read on EtoBox.
What is Inhibition of Lysyl Oxidase‐like 2 Overcomes Adhesion‐dependent Drug Resistance in the Collagen‐enriched Liver Cancer Microenvironment about?
## Abstract The tumor microenvironment (TME) is considered to be one of the vital mediators of tumor progression. Extracellular matrix (ECM), infiltrating immune cells, and stromal cells collectively constitute the complex ecosystem with varied biochemical and biophysical properties. The development of liver cancer is strongly tied with fibrosis and cirrhosis that alters the microenvironmental landscape, especially ECM composition. Enhanced deposition and cross‐linking of type I collagen are frequently detected in patients with liver cancer and have been shown to facilitate tumor growth and metastasis by epithelial‐to‐mesenchymal transition. However, information on the effect of collagen enrichment on drug resistance is lacking. Thus, the present study has comprehensively illustrated phenotypical and mechanistic changes in an __in vitro__ mimicry of collagen‐enriched TME and revealed that collagen enrichment could induce 5‐fluorouracil (5FU) and sorafenib resistance in liver cancer cells through hypoxia‐induced up‐regulation of lysyl oxidase‐like 2 (__LOXL2__). LOXL2, an enzyme that facilitates collagen cross‐linking, enhances cell adhesion‐mediated drug resistance by activating th
Who reads Inhibition of Lysyl Oxidase‐like 2 Overcomes Adhesion‐dependent Drug Resistance in the Collagen‐enriched Liver Cancer Microenvironment?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lanqi Gong; Yu Zhang; Yuma Yang; Qian Yan; Jifeng Ren; Jie Luo; Yuen Chak Tiu; Xiaona Fang; Beilei Liu; Raymond Hiu Wai Lam; Ka‐On Lam; Anne Wing‐Mui Lee; Xin‐Yuan Guan
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)