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Preliminary Clinical Effect Evaluation of Resveratrol in Adults with Allergic Rhinitis by Chunjiang Lv; Yongsheng Zhang; Lili Shen is a Medicine article available to read on EtoBox.

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**__Background:__** Resveratrol is a natural, nonflavonoid polyphenol, exerting anti-inflammatory activity. It has been reported that resveratrol, together with carboxymethyl-β-glucan, can reduce nasal symptoms in children with allergic rhinitis (AR). In this study, the effect of resveratrol on nasal symptoms in adults with AR was investigated. **__Methods:__** We conducted a placebo-controlled, double-blinded study. One hundred and fifty-one adults (aged 18–60 years) with severe persistent AR were divided into a placebo-treated group (__n__ = 50), a positive control budesonide-treated group (__n__ = 50), and a resveratrol-treated group (__n__ = 51). They were then treated with 2 sprays (100 μL/spray) in each nostril 3 times/day for 1 month. Nasal symptoms including obstruction, itching, sneezing, and rhinorrhea, and the levels of IgE, IL-4, TNF-α, and eosinophils in the blood were assessed at baseline and after treatment. **__Results:__** Adults treated with resveratrol or budesonide achieved a significant reduction in nasal symptoms compared to the placebo-treated group. The resveratrol treatment significantly decreased the IgE, IL-4, TNF-α, and eosinophil levels in the blood. In

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Author

Chunjiang Lv; Yongsheng Zhang; Lili Shen

Publisher

S. Karger AG

Published

2018

Language

EN

Field

Medicine (Health Sciences)