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Dysregulation of complement system during pregnancy in patients with preeclampsia: A prospective study by He, Ying-dong; Xu, Bing-ning; Wang, Meng-lu; Wang, Ya-qin; Yu, Feng; Chen, Qian; Zhao, Ming-hui is a Immunology and Microbiology article available to read on EtoBox.

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Recent studies have shown that aberrant activation of the complement system plays an important role in the pathogenesis of preeclampsia. There is evidence to suggest that aberrant activation of the complement system may already be present during the first trimester. Here, we performed a prospective study in which peripheral blood samples were collected from 500 women during pregnancy. Twenty-one patients (41 specimens) suffering from preeclampsia later in pregnancy were classified into the study group, and sixty-three gravidas with normal pregnancies (136 specimens) were selected as the control group. The plasma concentrations of complement factor B (CFB), C1q, complement factor H (CFH), C3c, C4, C3a, C5a and soluble C5b-9 (sC5b-9) were measured. The levels of CFB (P = 0.004), CFH (P = 0.002), C1q (P = 0.044), C3c (P = 0.032) and C4 (P = 0.015) were significantly higher in preeclampsia than in normal pregnancy during the first trimester, and these levels became similar to those in normal pregnancy thereafter. Before the onset of preeclampsia, the levels of C3a, C5a and sC5b-9 in the preeclampsia group were similar to those in control group even in late pregnancy. C3a levels showed

Who reads Dysregulation of complement system during pregnancy in patients with preeclampsia: A prospective study?

Author

He, Ying-dong; Xu, Bing-ning; Wang, Meng-lu; Wang, Ya-qin; Yu, Feng; Chen, Qian; Zhao, Ming-hui

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0161-5890)

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)