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Host protection against deliberate bacterial contamination of an extracellular matrix bioscaffold versus DacronTM mesh in a dog model of orthopedic soft tissue repair by Stephen F. Badylak; Ching Ching Wu; Melissa Bible; Edward McPherson is a Medicine article available to read on EtoBox.

What is Host protection against deliberate bacterial contamination of an extracellular matrix bioscaffold versus DacronTM mesh in a dog model of orthopedic soft tissue repair about?

## Abstract The resistance of two biomaterials, one synthetic and one biologic in origin, to deliberate bacterial infection was compared in a dog model of orthopedic soft tissue reconstruction. Twenty‐four adult female dogs were randomly divided into two equal groups and a 2.0‐cm‐round full‐thickness defect was created on the lateral surface of the stifle joint, leaving only the synovium and skin intact. The defect was surgically repaired with either DacronTM mesh or a porcine derived extracellular matrix (ECM) scaffold material. The repair site was inoculated with 1 × 10^8^ __Staphylococcus aureus__ at the time of surgery and the dogs were survived for 28 days. Results showed a chronic pyogranulomatous inflammatory response at the DacronTM implant sites versus a constructive tissue‐remodeling response without residual inflammation at the ECM implant site. Three dogs in the group receiving the DacronTM mesh were treated with KeflexTM (500 mg bid × 7 days) for signs of septicemia. A quantitative bacterial count of the implant sites at the time of sacrifice showed 6.52 × 10^5^ ± 1.2 × 10^6^ and 6.5 × 10^2^ ± 1.8 × 10^3^ bacteria per gram of tissue for the DacronTM and ECM scaffold si

Who reads Host protection against deliberate bacterial contamination of an extracellular matrix bioscaffold versus DacronTM mesh in a dog model of orthopedic soft tissue repair?

Author

Stephen F. Badylak; Ching Ching Wu; Melissa Bible; Edward McPherson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2003

Language

EN

Field

Medicine (Health Sciences)