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The ovarian hormones and absence epilepsy: a long-term EEG study and pharmacological effects in a genetic absence epilepsy model by Gilles van Luijtelaar; Bogusława Budziszewska; Lucylla Jaworska-Feil; Jules Ellis; Anton Coenen; Władysław Lasoń is a Medicine article available to read on EtoBox.
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In the first experiment, the relationship between the phase of the estrous cycle and the number of spontaneously occurring spike-wave discharges was investigated in WAG/Rij rats, a model for generalized absence epilepsy. The electroencephalogram (EEG) was continuously recorded for 96 h in eight rats chronically equipped with cortical EEG electrodes. A circadian pattern emerged for the number of spike-wave discharges: a nadir during the first hours of the light period, and an acrophase during the first hours of the dark period. This daily maximum was increased at proestrus day compared with the other days of the cycle, when the plasma level of progesterone is enhanced specifically at these hours of this day. This suggests that progesterone enhances spike-wave discharges. There was no difference in the first few hours of the light period in the number of spike-wave discharges between proestrus and the three other days, suggesting that estradiol has no effect on spike-wave discharges. In the second study, the effects of the systemic administration of progesterone and 17b-estradiol on spike-wave discharges and spontaneous behavior were investigated. It was shown that progesterone (20 a
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- Author
- Gilles van Luijtelaar; Bogusława Budziszewska; Lucylla Jaworska-Feil; Jules Ellis; Anton Coenen; Władysław Lasoń
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)