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The study investigates the role of oxidized low-density lipoprotein (oxLDL) in macrophage gene expression regulation through PPARg activation, highlighting its significance in atherosclerosis. It identifies 9-HODE and 13-HODE as key oxidized lipid components that act as PPARg ligands, promoting macrophage differentiation and inflammatory gene expression. The findings suggest a novel mechanism linking oxLDL to the transcriptional control of macrophage functions, which may contribute to the development of ath

Author
it's me ebeth tjhin
Language
EN

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