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Composition and conservation of the mRNA-degrading machinery in bacteria by Vladimir R Kaberdin; Dharam Singh; Sue Lin-Chao is a Medicine article available to read on EtoBox.

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RNA synthesis and decay counteract each other and therefore inversely regulate gene expression in pro- and eukaryotic cells by controlling the steady-state level of individual transcripts. Genetic and biochemical data together with recent in depth annotation of bacterial genomes indicate that many components of the bacterial RNA decay machinery are evolutionarily conserved and that their functional analogues exist in organisms belonging to all kingdoms of life. Here we briefly review biological functions of essential enzymes, their evolutionary conservation and multienzyme complexes that are involved in mRNA decay in __Escherichia coli__ and discuss their conservation in evolutionarily distant bacteria.

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Author

Vladimir R Kaberdin; Dharam Singh; Sue Lin-Chao

Publisher

BioMed Central; Springer (Biomed Central Ltd.); BioMed Central Ltd.; [Basel Switzerland]: Karger; London: 2009-; Springer Science and Business Media LLC; S. Karger AG; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1021-7770)

Published

2011

Language

EN

Field

Medicine (Life Sciences)