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Determination of CYP2C19 phenotype in black Americans with omeprazole: Correlation with genotype* by Marinac, Jacqueline S.; Balian, John D.; Foxworth, John W.; Willsie, Sandra K.; Daus, Jennifer C.; Owen, Renius; Flockhart, David A. is a Medicine article available to read on EtoBox.
What is Determination of CYP2C19 phenotype in black Americans with omeprazole: Correlation with genotype* about?
Our objective was to study omeprazole as a single-dose oral probe in the determination of CYP2C19 phenotype in black subjects and to determine the correlation between phenotype and genotype. Methods: This single-dose, open-label outpatient study was conducted at a community-based, universityafliliated teaching hospital outpatient cliic. Study subjects were 100 healthy, unrelated black adults (age range, 18 to 50 years) who were receiving no medications. Baseline omeprazole and 2-hour postingestion omeprazole and 5'-hydroxyomeprazole concentrations were measured for phenotype determination. Identification of CYP2Cl9,, genotypes were performed with use of the polymerase chain reaction. Results: Results were obtained for 28 men and 72 women. Ninety-eight subjects were found to be phenotypically extensive metabolizers and two to be poor metabolizers (one man; one smoker). Genotype determination revealed that the two poor metabolizers of omeprazole were homozygous for a single base pair mutation (ml/ml) in exon 5 of CYP2Cl9. Twenty-eight of the extensive metabolizers were heterozygous (ml/wt) and the remaining 70 were homozygous (wt/wt). No side effects were reported. Conclusions: The 2
Who reads Determination of CYP2C19 phenotype in black Americans with omeprazole: Correlation with genotype*?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Marinac, Jacqueline S.; Balian, John D.; Foxworth, John W.; Willsie, Sandra K.; Daus, Jennifer C.; Owen, Renius; Flockhart, David A.
- Publisher
- Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)