Can I read The prognostic values of tumor characteristics and clinical factors of neuroendocrine tumors: Two centers experience on EtoBox?

The prognostic values of tumor characteristics and clinical factors of neuroendocrine tumors: Two centers experience by E. Sezer; K. Eser; V. Ercolak; Y. Acıkgoz; B. Ozturk is a Medicine article available to read on EtoBox.

What is The prognostic values of tumor characteristics and clinical factors of neuroendocrine tumors: Two centers experience about?

Introduction: Anal squamous cell carcinomas (ASCC) account for approximately 2% of all gastrointestinal malignancies. The annual incidence of ASCC has increased by 2.9% per year in recent decades. In 2012, according to GLOBOCAN, 40,000 cases of anal cancer were reported worldwide, 35,000 (87%) attributable to HPV, being HPV-16 the most frequent serotype. A highly active HPV infection is associated with a more immunogenic tumor microenvironment with strong expression of immune markers, such as CD8þ and PD-1þ tumor infiltrating lymphocytes (TILs), PD-L1þ, FOXP3þ Tregs, caspase 8. Methods: 52 FFPE samples of patients with histologically confirmed ASCC were analyzed for HPV genotyping. The DNA, from the histological sections (previous step of deparaffinization) and the swab cells were purified using the QIAamp DNA Mini Kit that included 36 HPV genotypes. A retrospective review of the medical records was performed to correlate clinical data and treatment response with HPV results. The FFPE samples analyzed were exclusively obtained from the primary tumor. The selection was identified as a random sample of patients with FFPE available for HPV analysis, but were not selected by behavioral

Who reads The prognostic values of tumor characteristics and clinical factors of neuroendocrine tumors: Two centers experience?

Author

E. Sezer; K. Eser; V. Ercolak; Y. Acıkgoz; B. Ozturk

Publisher

Oxford University Press; Elsevier BV (ISSN 0923-7534)

Published

2018

Language

EN

Field

Medicine (Health Sciences)