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Antipsychotics-induced ischaemic colitis and gastrointestinal necrosis: a review of the French pharmacovigilance database by Hélène Peyrière; Clarisse Roux; Claire Ferard; Nathalie Deleau; Carmen Kreft-Jais; D. Hillaire-Buys; Jean-Philippe Boulenger; Jean-Pierre Blayac is a Medicine article available to read on EtoBox.
What is Antipsychotics-induced ischaemic colitis and gastrointestinal necrosis: a review of the French pharmacovigilance database about?
## Abstract ## Purpose First‐ and second‐generation antipsychotics commonly cause mild gastrointestinal hypomotility. Intestinal necrosis may be a consequence of such gastrointestinal perturbations. ## Material and Methods We reviewed all the observations of ischaemic colitis and gastrointestinal necrosis notified to the French Pharmacovigilance database (FPD) between 1997 and the end of 2006. ## Results Thirty‐eight cases of ischaemic colitis and gastrointestinal necrosis associated with antipsychotics were analysed. The average age of the patients was 42.7 ± 14.7 years (15–77 years). The digestive complication was an intestinal necrosis in 27 cases, an ischaemic colitis in 10 cases (with perforation in three cases), and one perforation. Surgical procedure (partial or total resection of the colon and/or small intestine) was performed in 24 patients. Six patients died despite surgery. Among the whole population, the outcome was fatal in 14 patients, 13 patients recovered with sequelae, six patients fully recovered, and the outcome remained unknown in five cases. In 55.2% of the cases, the patients were treated with more than one antipsychotic medication. The most frequently involve
Who reads Antipsychotics-induced ischaemic colitis and gastrointestinal necrosis: a review of the French pharmacovigilance database?
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- Author
- Hélène Peyrière; Clarisse Roux; Claire Ferard; Nathalie Deleau; Carmen Kreft-Jais; D. Hillaire-Buys; Jean-Philippe Boulenger; Jean-Pierre Blayac
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)