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Supramolecular Tripeptide Self-assembly Initiated at the Surface of Coacervates by Polyelectrolyte Exchange by Miryam Criado-Gonzalez; Deborah Wagner; Muhammad Haseeb Iqbal; Aymeric Ontani; Alain Carvalho; Marc Schmutz; Joseph B. Schlenoff; Pierre Schaaf; Loïc Jierry; Fouzia Boulmedais is a Chemistry article available to read on EtoBox.
What is Supramolecular Tripeptide Self-assembly Initiated at the Surface of Coacervates by Polyelectrolyte Exchange about?
Spatial control of supramolecular self-assembly can yield compartmentalized structures, a key feature for the design of artificial cells. Inducing self-assembly from and on compartments is still a challenge. Polyelectrolyte complex coacervates are simple model droplet systems able to reproduce the basic features of membrane-less organelles, appearing in cells. Here, we demonstrate the supramolecular self-assembly of a phosphorylated tripeptide, Fmoc-FFpY (Fmoc: fluorenyl-methoxycarbonyl; F: phenyl alanine, pY: phosphorylated tyrosine), on the surface of poly(l-glutamic acid)/poly(allylamine hydrochloride) (PGA/PAH) complex coacervate microdroplets. The phosphorylated peptides self-assemble, without dephosphorylation, through ion pairing between the phosphate groups of Fmoc-FFpY and the amine groups of PAH. This process provides spontaneous capsules formed by an amorphous polyelectrolyte complex core surrounded by a structured peptide/PAH shell. Similar fibrillar Fmoc-FFpY self-assembled structures are obtained at the interface between the peptide solution and a PGA/PAH polyelectrolyte multilayer, a complex coacervate in the thin film or "multilayer" format. In contact with the pept
Who reads Supramolecular Tripeptide Self-assembly Initiated at the Surface of Coacervates by Polyelectrolyte Exchange?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Miryam Criado-Gonzalez; Deborah Wagner; Muhammad Haseeb Iqbal; Aymeric Ontani; Alain Carvalho; Marc Schmutz; Joseph B. Schlenoff; Pierre Schaaf; Loïc Jierry; Fouzia Boulmedais
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)