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Meta-Analysis of Prognosis of Different Treatments for Symptomatic Moyamoya Disease by Qifeng Li; Yalong Gao; Wenqiang Xin; Ziwei Zhou; Hongtao Rong; Yafei Qin; Ke Li; Yuan Zhou; Jiwei Wang; Jianhua Xiong; Xinlong Dong; Mengchen Yang; Yixin Liu; Jun Shen; Guangen Wang; Aiguo Song; Jianning Zhang is a Medicine article available to read on EtoBox.

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## Objective: The purpose of this study was to evaluate the efficacy of surgical revascularization versus conservative treatment and different surgical modalities, in order to provide evidence for the patient with moyamoya disease (mmd) to choose the appropriate treatment. ## Methods: We comprehensively searched pubmed, embase, web of science, and the cochrane library for articles published regarding mmd treatment. if the i value, which evaluated the heterogeneity, was <50%, a fixed-effect model was used; if not, a random effect model was applied. ## Results: Twenty-seven articles were included in the meta-analysis. the surgery group is more advantageous in reducing the risk of future stroke events than conservative treatment in mmd patients (odds ratio [or] 0.26, 95% confidence interval [ci] 0.20-0.33, p < 0.001). in addition, the surgical group also had an advantage in terms of increased cerebral perfusion (or 7.16, 95% ci 3.28-15.64, p < 0.001) and death due to rebleeding (or 0.27, 95% ci 0.10-0.72, p < 0.01). direct surgery showed a significant efficacy over indirect surgery (or 2.03, 95% ci 1.32-3.13, p < 0.01). no obvious difference was found between the direct and indirect b

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Author

Qifeng Li; Yalong Gao; Wenqiang Xin; Ziwei Zhou; Hongtao Rong; Yafei Qin; Ke Li; Yuan Zhou; Jiwei Wang; Jianhua Xiong; Xinlong Dong; Mengchen Yang; Yixin Liu; Jun Shen; Guangen Wang; Aiguo Song; Jianning Zhang

Publisher

Elsevier BV

Published

2019

Language

EN

Field

Medicine (Health Sciences)