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Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents by Xueping Zhang; Kendra M. Haney; Amanda C. Richardson; Eden Wilson; David A. Gewirtz; Joy L. Ware; Zendra E. Zehner; Yan Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Accumulating evidence indicates that the chemokine receptor CCR5 and the chemokine CCL5 may be involved in the proliferation and metastasis of prostate cancer. Consequently, chemokine receptor CCR5 antagonists could potentially act as anti-prostate cancer agents. As the first natural product CCR5 antagonist, anibamine provides a novel chemical structural skeleton compared with other known antagonists identified through high-throughput screening. Our studies demonstrate that anibamine produces significant inhibition of prostate cancer cell proliferation at micromolar to submicromolar concentrations as well as suppressing adhesion and invasion of the highly metastatic M12 prostate cancer cell line. Preliminary in vivo studies indicate that anibamine also inhibits prostate tumor growth in mice. These findings indicate that anibamine may prove to be a novel lead compound for the development of prostate cancer therapeutic agents.

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Author

Xueping Zhang; Kendra M. Haney; Amanda C. Richardson; Eden Wilson; David A. Gewirtz; Joy L. Ware; Zendra E. Zehner; Yan Zhang

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)