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Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial by François Meyer; Pilar Galan; Pierre Douville; Isabelle Bairati; Pastelle Kegle; Sandrine Bertrais; Carla Estaquio; Serge Hercberg is a Medicine article available to read on EtoBox.

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## Abstract Randomized trials have shown, unexpectedly, that supplementation with selenium or vitamin E is associated with a reduction of prostate cancer risk. We assess whether a supplementation with low doses of antioxidant vitamins and minerals could reduce the occurrence of prostate cancer and influence biochemical markers. The SU.VI.MAX trial comprised 5,141 men randomized to take either a placebo or a supplementation with nutritional doses of vitamin C, vitamin E, β‐carotene, selenium and zinc daily for 8 years. Biochemical markers of prostate cancer risk such as prostate‐specific antigen (PSA) and insulin‐like growth factors (IGFs) were measured on plasma samples collected at enrollment and at the end of follow‐up from 3,616 men. Cox regression models were used to estimate the hazard ratio and related 95% confidence interval of prostate cancer associated with the supplementation and to examine whether the effect differed among predetermined susceptible subgroups. During the follow‐up, 103 cases of prostate cancer were diagnosed. Overall, there was a moderate nonsignificant reduction in prostate cancer rate associated with the supplementation (hazard ratio = 0.88; 95% CI = 0.

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Author

François Meyer; Pilar Galan; Pierre Douville; Isabelle Bairati; Pastelle Kegle; Sandrine Bertrais; Carla Estaquio; Serge Hercberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2005

Language

EN

Field

Medicine (Health Sciences)