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Use of Beta‐2 Agonists and Risk of Hip/femur Fracture: a Population‐based Case‐control Study by Frank de Vries; Sander Pouwels; Madelon Bracke; Hubert G.M. Leufkens; Cyrus Cooper; Jan‐Willem J. Lammers; Tjeerd‐Pieter van Staa is a Medicine article available to read on EtoBox.
What is Use of Beta‐2 Agonists and Risk of Hip/femur Fracture: a Population‐based Case‐control Study about?
## Abstract ## Introduction Administration of beta‐2 agonists decreased bone mineral density in rats. But the association between bronchodilators and fracture risk has not been studied in humans. ## Objectives To examine the association between use of beta‐2 agonists and risk of hip/femur fracture. ## Methods We conducted a population‐based case‐control study (6763 cases) in the Dutch PHARMO database. Current beta‐2 agonist use was compared to never use. We adjusted for severity of the underlying respiratory disease and disease and drug history. ## Results A hospitalisation for asthma/COPD in the year before index date increased risk of hip/femur fracture: crude OR 2.17 (95% CI, 1.41–3.34). Patients using higher doses of beta‐2 agonists had increased risk of hip/femur fracture: crude OR 1.94 (95% CI, 1.41–2.66) for daily dosages of ≥1600 μg albuterol equivalent. The excess fracture risk reduced after adjustment for disease severity (1.46; 95% CI, 1.02–2.08) and after exclusion of oral glucocorticoid users (1.31; 95% CI, 0.80–2.15). Risk of hip/femur fracture was similar between users of beta‐2 agonists, inhaled glucocorticoids and anticholinergics. ## Conclusion We found increases
Who reads Use of Beta‐2 Agonists and Risk of Hip/femur Fracture: a Population‐based Case‐control Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Frank de Vries; Sander Pouwels; Madelon Bracke; Hubert G.M. Leufkens; Cyrus Cooper; Jan‐Willem J. Lammers; Tjeerd‐Pieter van Staa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)