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A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2 by Jo, Seri (author);Kim, Suwon (author);Yoo, Jahyun (author);Kim, Mi-Sun (author);Shin, Dong Hae (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A Study of 3CLpros as Promising Targets against SARS-CoV and SARS-CoV-2 about?

The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), results in serious chaos all over the world. In addition to the available vaccines, the development of treatments to cure COVID-19 should be done quickly. One of the fastest strategies is to use a drug-repurposing approach. To provide COVID-19 patients with useful information about medicines currently being used in clinical trials, twenty-four compounds, including antiviral agents, were selected and assayed. These compounds were applied to verify the inhibitory activity for the protein function of 3CLpros (main proteases) of SARS-CoV and SARS-CoV-2. Among them, viral reverse-transcriptase inhibitors abacavir and tenofovir revealed a good inhibitory effect on both 3CLpros. Intriguingly, sildenafil, a cGMP-specific phosphodiesterase type 5 inhibitor also showed significant inhibitory function against them. The in silico docking study suggests that the active-site residues located in the S1 and S2 sites play key roles in the interactions with the inhibitors. The result indicates that 3CLpros are promising targets to cope with SAR-CoV-2 and its variants. The info

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Author

Jo, Seri (author);Kim, Suwon (author);Yoo, Jahyun (author);Kim, Mi-Sun (author);Shin, Dong Hae (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)