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NLRP3 inflammasome: A potential therapeutic target to minimize renal ischemia/reperfusion injury during transplantation by Xiaochen Su; Bin Liu; Shangguo Wang; Yuxiong Wang; Zehua Zhang; Honglan Zhou; Faping Li is a Medicine article available to read on EtoBox.

What is NLRP3 inflammasome: A potential therapeutic target to minimize renal ischemia/reperfusion injury during transplantation about?

Renal transplantation is currently the best treatment option for patients with end-stage kidney disease. Ischemia/reperfusion injury (IRI), which is an inevitable event during renal transplantation, has a profound impact on the function of transplanted kidneys. It has been well demonstrated that innate immune system plays an important role in the process of renal IRI. As a critical component of innate immune system, Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has received great attention from scientific community over the past decade. The main function of NLRP3 inflammasome is mediating activation of caspase-1 and maturation of interleukin (IL)-1β and IL-18. In this review, we summarize the associated molecular signaling events about NLRP3 inflammasome in renal IRI, and highlight the possibility of targeting NLRP3 inflammasome to minimize renal IRI during transplantation.

Who reads NLRP3 inflammasome: A potential therapeutic target to minimize renal ischemia/reperfusion injury during transplantation?

Author

Xiaochen Su; Bin Liu; Shangguo Wang; Yuxiong Wang; Zehua Zhang; Honglan Zhou; Faping Li

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)