About this Neuroscience article
Effects of Estrogen and Progesterone on the Neurogenic Inflammatory Neuropeptides: Implications for Gender Differences in Migraine by Ayhan Cetinkaya; Erkan Kilinc; Cagri Camsari; Muhammed Nur Ogun is a Neuroscience article available to read on EtoBox.
Neurogenic inflammation including calcitonin gene-related peptide (CGRP) and substance-P (SP) release plays a pivotal role in migraine pathogenesis. Prevalence of migraine is ~ 3 folds higher in women than in men, but its underlying mechanisms remained unclear. We investigated the effects of female sex hormones estrogen and progesterone on CGRP and SP in in-vivo and ex-vivo in rats of both sexes. For in-vivo experiments, male, female and ovariectomized rats were separated into four groups (n = 7) as control, estrogen, progesterone and estrogen + progesterone, respectively. Groups received daily intraperitoneal vehicle, 17β-estradiol, progesterone and 17β-estradiol + progesterone for 5 days, respectively. For ex-vivo experiments in both sexes, isolated trigeminal ganglia and hemiskull preparations were divided into four groups (n = 6 or 8), respectively, as in-vivo groups, and administered the same test substances. CGRP and SP contents in plasma and superfusates were determined using ELISA. In in-vivo experiments, 17β-estradiol decreased CGRP levels in males and SP levels in ovariectomized rats. Progesterone increased both CGRP and SP levels in females. Their combination decreased b
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- Author
- Ayhan Cetinkaya; Erkan Kilinc; Cagri Camsari; Muhammed Nur Ogun
- Publisher
- Springer Science and Business Media LLC
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)