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Evaluation of Biodegradable Polyesters Modified by Type II Collagen and Arg‐Gly‐Asp as Tissue Engineering Scaffolding Materials for Cartilage Regeneration by Shan‐hui Hsu; Shih‐Hau Chang; Hung‐Jen Yen; Shu Wen Whu; Ching‐Lin Tsai; David Chanhen Chen is a Medicine article available to read on EtoBox.
What is Evaluation of Biodegradable Polyesters Modified by Type II Collagen and Arg‐Gly‐Asp as Tissue Engineering Scaffolding Materials for Cartilage Regeneration about?
**Abstract:** Synthetic biodegradable polyesters poly(l‐lactide) (PLLA) and poly(d,l‐lactide‐coglycolide) (PLGA) (50:50) modified by porcine type II collagen and an Arg‐Gly‐Asp (RGD)‐containing protein were evaluated as scaffolds for cartilage regeneration in this study. Cytocompatibility of the polymer films was tested using immortalized chondrocytes. Neocartilage formation in vitro on cell‐seeded scaffolds was further examined using primary porcine chondrocytes. The inflammatory response of the scaffolds was evaluated subcutaneously in rats. A pilot animal study was conducted, in which rabbit allogeneic chondrocyte‐seeded scaffolds were implanted to repair the defected rabbit knee cartilage. The results demonstrated that PLGA as well as its blends with PLLA had better cell growth than pure PLLA, and that type II collagen enhanced, but RGD inhibited cell proliferation. Scaffolds made of blended PLLA/PLGA had larger dynamic compressive modulus compared to scaffolds made of PLLA or PLGA single polymer. Chondrocyte‐seeded scaffolds modified by type II collagen without RGD had the greater number of cells as well as higher glycosaminoglycan (GAG) and collagen contents compared to scaff
Who reads Evaluation of Biodegradable Polyesters Modified by Type II Collagen and Arg‐Gly‐Asp as Tissue Engineering Scaffolding Materials for Cartilage Regeneration?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shan‐hui Hsu; Shih‐Hau Chang; Hung‐Jen Yen; Shu Wen Whu; Ching‐Lin Tsai; David Chanhen Chen
- Publisher
- Wiley
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)