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Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells by Anatoli Melnikov; Olga Zaborina; Neelam Dhiman; B. S. Prabhakar; A. M. Chakrabarty; William Hendrickson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells about?
__Burkholderia cepacia__ is an emerging opportunistic pathogen that causes fatal infections in patients suffering from cystic fibrosis (CF) and chronic granulomatous disease. Various environmental isolates of __B. cepacia__ are, however, capable of degrading environmental pollutants, such as trichloroethylene, 2,4,5‐trichlorophenoxyacetic acid (2,4,5‐T), etc., and are also highly effective in controlling plant diseases caused by nematodes and fungi. Such strains have therefore been proposed for environmental release to clean up toxic dump sites or as biopesticides. Various efforts to distinguish between clinical and environmental isolates of __B. cepacia__ with regard to their virulence characteristics have produced ambiguous results, suggesting that newer methods are needed to test for the presence or absence of pathogenic potential in __B. cepacia__ strains proposed for environmental release. We now report that several clinical strains of __B. cepacia__ secrete cytotoxic factors that allow macrophage and mast cell death in the presence of external ATP. Several environmental strains had reduced activity in this regard. We also demonstrate that, while all the strains secrete enzyme
Who reads Clinical and environmental isolates of Burkholderia cepacia exhibit differential cytotoxicity towards macrophages and mast cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Anatoli Melnikov; Olga Zaborina; Neelam Dhiman; B. S. Prabhakar; A. M. Chakrabarty; William Hendrickson
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0950-382X)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)