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Quantitative proteomics analysis reveals important roles of N-glycosylation on ER quality control system for development and pathogenesis in Magnaporthe oryzae by Chen, Xiao-Lin; Liu, Caiyun; Tang, Bozeng; Ren, Zhiyong; Wang, Guo-Liang; Liu, Wende; Xu, Jin-Rong is a Medicine article available to read on EtoBox.
What is Quantitative proteomics analysis reveals important roles of N-glycosylation on ER quality control system for development and pathogenesis in Magnaporthe oryzae about?
Genetic studies have shown essential functions of N-glycosylation during infection of the plant pathogenic fungi, however, systematic roles of N-glycosylation in fungi is still largely unknown. Biological analysis demonstrated N-glycosylated proteins were widely present at different development stages of __Magnaporthe oryzae__ and especially increased in the appressorium and invasive hyphae. A large-scale quantitative proteomics analysis was then performed to explore the roles of N-glycosylation in __M__. __oryzae__. A total of 559 N-glycosites from 355 proteins were identified and quantified at different developmental stages. Functional classification to the N-glycosylated proteins revealed N-glycosylation can coordinate different cellular processes for mycelial growth, conidium formation, and appressorium formation. N-glycosylation can also modify key components in N-glycosylation, O-glycosylation and GPI anchor pathways, indicating intimate crosstalk between these pathways. Interestingly, we found nearly all key components of the endoplasmic reticulum quality control (ERQC) system were highly N-glycosylated in conidium and appressorium. Phenotypic analyses to the gene deletion m
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- Author
- Chen, Xiao-Lin; Liu, Caiyun; Tang, Bozeng; Ren, Zhiyong; Wang, Guo-Liang; Liu, Wende; Xu, Jin-Rong
- Publisher
- Public Library of Science; San Francisco CA: Public Library of Science, [2005]-; Public Library of Science (PLoS) (ISSN 1553-7366)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)