Can I read Diffusion- and T2-weighted MRI of closed-head injury in rats: A time course study and correlation with histology on EtoBox?

Diffusion- and T2-weighted MRI of closed-head injury in rats: A time course study and correlation with histology by Yaniv Assaf; Elie Beit-Yannai; Esther Shohami; Elisha Berman; Yoram Cohen is a Medicine article available to read on EtoBox.

What is Diffusion- and T2-weighted MRI of closed-head injury in rats: A time course study and correlation with histology about?

Diffusion-and T,-weighted MRI were used to evaluate changes in brain water characteristics following closed-head injury in rats. Images were collected within the first 2 h and at 24 h and 7 days following the traumatic event and then compared with histology. The ratios between the apparent diffusion coefficients (ADCs) of the traumatized tissues and normal brain tissues were significantly different from unity and were found to be 0.79 ? 0.25 (p < O.Ol), 0.49 5 0.33 (p < 0.0002), and 3.47 + 1.36 (p < 10m6) at l-2 h, 24 h, and 1 week after the trauma, respectively. In severe trauma, areas of hyperintensity which were not apparent on the Tz-weighted images could be detected on the diffusion-weighted images within l-2 h after the trauma. At 24 h following the traumatic event, large areas of hyperintensity are observed in both types of images. One week following the trauma, the ADCs of the traumatized tissues (1.84 5 0.69 x 10e5 cm%) are much larger than those of normal brain (0.57 2 0.19 x 1O-5 cm%) and approach the value of free water. At 7 days, the areas of hyperintensity in the T,-weighted images seem to underestimate the injured areas found by histology. At this time point a good

Who reads Diffusion- and T2-weighted MRI of closed-head injury in rats: A time course study and correlation with histology?

Author

Yaniv Assaf; Elie Beit-Yannai; Esther Shohami; Elisha Berman; Yoram Cohen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0730-725X)

Published

1997

Language

EN

Field

Medicine (Health Sciences)