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The study investigates the antimycobacterial activity of polyacetylenes extracted from the roots of Levisticum officinale, identifying 3(R)-falcarinol and 3(R)-8(S)-falcarindiol as the active compounds. These compounds demonstrated significant inhibitory effects against Mycobacterium fortuitum and Mycobacterium aurum, with minimal inhibitory concentrations (MIC) of 16.4 μM and 30.7 μM respectively. The findings suggest that the presence of a terminal methyl group is crucial for the antimycobacterial activit

Author

Natalie Szurzyński

Language

EN