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Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress by Angelike Triantafyllou; Alfiya Bikineyeva; Anna Dikalova; Rafal Nazarewicz; Stamatios Lerakis; Sergey Dikalov is a Medicine article available to read on EtoBox.
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## Abstract ## Background Gum of Chios mastic (__Pistacia lentiscus var. chia)__ is a natural antimicrobial agent that has found extensive use in pharmaceutical products and as a nutritional supplement. The molecular mechanisms of its anti-inflammatory activity, however, are not clear. In this work, the potential role of antioxidant activity of Chios mastic gum has been evaluated. ## Methods Scavenging of superoxide radical was investigated by electron spin resonance and spin trapping technique using EMPO spin trap in xanthine oxidase system. Superoxide production in endothelial and smooth muscle cells stimulated with TNF-α or angiotensin II and treated with vehicle (DMSO) or mastic gum (0.1-10 μg/ml) was measured by DHE and HPLC. Cellular H~2~O~2~ was measured by Amplex Red. Inhibition of protein kinase C (PKC) with mastic gum was determined by the decrease of purified PKC activity, by inhibition of PKC activity in cellular homogenate and by attenuation of superoxide production in cells treated with PKC activator phorbol 12-myristate 13-acetate (PMA). ## Results Spin trapping study did not show significant scavenging of superoxide by mastic gum itself. However, mastic gum inhibite
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- Author
- Angelike Triantafyllou; Alfiya Bikineyeva; Anna Dikalova; Rafal Nazarewicz; Stamatios Lerakis; Sergey Dikalov
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc.; Springer Nature (ISSN 1475-2891)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)