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## Abstract Bioactive glasses, originally developed to promote tissue adhesion, are finding an increasing array of biomedical applications. The aim of the current study was to assess the ability of silicate‐ and zinc phosphate‐based bioactive glasses to modulate the secretion of cytokines from activated human macrophages and monocytes. Human macrophages and monocytes were isolated and cultured on surfaces coated with a range of quantities of the bioactive glasses. Nontoxic concentrations of the glasses were selected and assessed further for their ability to modulate the secretion of tumor necrosis factor (TNF)‐α, interleukin (IL)‐10 and ‐6, in the presence or absence of the stimulant lipopolysaccharide. 45S5 glass produced a significant reduction to the amount of TNF‐α (__p__ < 0.05) and IL‐6 (__p__ < 0.01) secreted by stimulated cells compared with cells stimulated in the absence of bioactive glass. A significant reduction in IL‐6 secretion was also observed with the other silicate‐ and zinc phosphate‐based glasses tested. IL‐10 secretion was increased (but not significantly) in presence of all glasses tested. TNF‐α and IL‐6 secretion from stimulated cells was lower in presence of

Who reads Effect of Particulate Bioactive Glasses on Human Macrophages and Monocytes in Vitro?

Author

Richard M. Day; Aldo R. Boccaccini

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2005

Language

EN

Field

Engineering (Physical Sciences)