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BCR-ABL P190 in ALL Diagnosis and Prognosis by Luana M is a document available to read on EtoBox.
This document discusses the role of the BCR-ABL P190 fusion gene in the diagnosis and prognosis of acute lymphoblastic leukemia (ALL) patients. It notes that the Philadelphia chromosome, resulting from the translocation of the BCR and ABL genes, produces the BCR-ABL tyrosine kinase which is associated with poor prognosis in ALL. The BCR-ABL P190 variant specifically occurs in Philadelphia positive ALL and results in increased tyrosine kinase activity and proliferation of leukemic cells. Determining the pres
- Author
- Luana M
- Language
- EN