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Development of a New Technique for Reducing Pressure Pulse Generation During 308‐Nm Excimer Laser Coronary Angioplasty by James E. Tcheng; Lisa D. Wells; Harry R. Phillips; Lawrence I. Deckelbaum; Robert A. Golobic is a Medicine article available to read on EtoBox.

What is Development of a New Technique for Reducing Pressure Pulse Generation During 308‐Nm Excimer Laser Coronary Angioplasty about?

Despite expectations that excimer laser ablation would result in a low incidence of coronary dissection, studies have documented a 15-20% incidence of dissection (including a 4-67'0 incidence of clinically significant dissection) during excimer interventions. This investigation sought to determine if pressure pulses produced by the exposure of fluid phase media (blood and contrast) to 308-nm excimer radiation might contribute to untoward outcomes. Pressure pulses generated in these media were quantitated to be >I00 atm. In vitro ablation of porcine aorta in the presence of blood or contrast resulted in tissue dissection, while ablation in pure crystalloid did not. Next, a "flush and bathe" technique designed to replace all blood and contrast with crystalloid was applied to a pilot population of 57 consecutive patients. There were no rhythm disturbances or laserrelated clinically significant dissections in this group, and the clinical success rate was 95%. In summary, this report quantitates a potential etiology for excimer dissection and suggests that replacement of blood and contrast with crystalloid might improve procedural and clinical success rates. o 1995 Wiley-Liss, Inc.

Who reads Development of a New Technique for Reducing Pressure Pulse Generation During 308‐Nm Excimer Laser Coronary Angioplasty?

Author

James E. Tcheng; Lisa D. Wells; Harry R. Phillips; Lawrence I. Deckelbaum; Robert A. Golobic

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-6569)

Published

1995

Language

EN

Field

Medicine (Health Sciences)