Can I read Implications of Genetic Traits on Vaccine Efficacy on EtoBox?

Implications of Genetic Traits on Vaccine Efficacy by B. N. Murthy is a Mathematics article available to read on EtoBox.

What is Implications of Genetic Traits on Vaccine Efficacy about?

## Abstract Literature on genetic screening in the community suggests that people having specific genotypes may either get or protect from infection, for example, malaria, human papiloma virus, and haemophilic influenza, for which vaccines are either already developed or being targeted. In such a situation, the evaluation of the efficacy of vaccine in the community needs to be examined with caution. In this paper, I present a method for the estimation of vaccine efficacy (VE) in the presence of genetic traits/component (θ) and the sample size required to estimate the 95 per cent CI with a given relative width for the estimated vaccine efficacy. Considering true efficacy ranging from 40 to 80 per cent and the possible values of the genetic component (θ) ranging from 0 to 60 per cent, the VE was estimated. The 95 per cent confidence intervals (CI) for the estimated VE for relative widths (R) 1.0 and 0.1 were computed. The sample sizes required for each of the unvaccinated and vaccinated cohorts were computed for estimating the 95 per cent CI for given incidence rates in the unvaccinated (Iu) cohort. In the presence of genetic traits I found that the VE was consistently overestimated.

Who reads Implications of Genetic Traits on Vaccine Efficacy?

Author

B. N. Murthy

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0277-6715)

Published

2003

Language

EN

Field

Mathematics (Physical Sciences)