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Cabozantinib inhibits HBV-RNA transcription by decreasing STAT3 binding to the enhancer region of cccDNA by Kazuyoshi Funato; Nozomi Miyake; Kazuma Sekiba; Yu Miyakawa; Takahiro Seimiya; Chikako Shibata; Takahiro Kishikawa; Motoyuki Otsuka is a Medicine article available to read on EtoBox.

What is Cabozantinib inhibits HBV-RNA transcription by decreasing STAT3 binding to the enhancer region of cccDNA about?

## Background: Precision medicine and customized therapeutics based on the features of each patient are important for maximizing therapeutic effects. Because most cases of HCC occur in the damaged liver through various etiologies, such as hepatitis virus infection, steatohepatitis, and autoimmune hepatitis, there should be a rationale for the choice of therapeutic options based on these etiologies. Although cabozantinib, an oral multikinase inhibitor, has demonstrated clinical effectiveness in advanced HCC, subgroup analyses showed a lower HR for death in HBV-related HCC. This study aimed to determine the therapeutic effects of cabozantinib in HBV-related HCC. ## Methods: Using HBV infection models and gene knockout cells, we determined the crucial signaling axis responsible for the effects of cabozantinib on HBV. A chromatin immunoprecipitation assay was performed to determine the interaction between the signaling molecules and HBV DNA. Agonists and inhibitors were used for confirmation. ## Results: Cabozantinib inhibited HBV replication through the HGF-mesenchymal-epithelial transition factor–signal transducer and activator of transcription 3 (MET-STAT3) signaling axis. The impor

Who reads Cabozantinib inhibits HBV-RNA transcription by decreasing STAT3 binding to the enhancer region of cccDNA?

Author

Kazuyoshi Funato; Nozomi Miyake; Kazuma Sekiba; Yu Miyakawa; Takahiro Seimiya; Chikako Shibata; Takahiro Kishikawa; Motoyuki Otsuka

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023

Field

Medicine (Health Sciences)