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Can I read On-chip recapitulation of the tumor microenvironment: A decade of progress on EtoBox?
On-chip recapitulation of the tumor microenvironment: A decade of progress by S.M. Giannitelli; V. Peluzzi; S. Raniolo; G. Roscilli; M. Trombetta; P. Mozetic; A. Rainer is a Engineering article available to read on EtoBox.
What is On-chip recapitulation of the tumor microenvironment: A decade of progress about?
One of the hurdles to the development of new anticancer therapies is the lack of in vitro models which faithfully reproduce the in vivo tumor microenvironment (TME). Understanding the dynamic relationships between the components of the TME in a controllable, scalable, and reliable setting would indeed support the discovery of biological targets impacting cancer diagnosis and therapy. Cancer research is increasingly shifting from traditional two-dimensional (2D) cell culture toward threedimensional (3D) culture models, which have been demonstrated to increase the significance and predictive value of in vitro data. In this scenario, microphysiological systems (also known as organs-on-chip) have emerged as a relevant technological platform enabling more predictive investigation of cell-cell and cell-ECM interplay in cancer, attracting a significant research effort in the last years. This review illustrates one decade of progress in the field of tumor-microenvironment-on-chip (TMOC) approaches, exploiting either cell-laden microfluidic chambers or microfluidic confined tumor spheroids to model the TME. TMOCs have been designed to recapitulate several aspects of the TME, including tumor
Who reads On-chip recapitulation of the tumor microenvironment: A decade of progress?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- S.M. Giannitelli; V. Peluzzi; S. Raniolo; G. Roscilli; M. Trombetta; P. Mozetic; A. Rainer
- Publisher
- Elsevier BV
- Published
- 2024
- Language
- EN
- Field
- Engineering (Physical Sciences)