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Can I read Pilot Study of Celecoxib and Infusional 5-Fluorouracil as Second-line Treatment for Advanced Pancreatic Carcinoma on EtoBox?
Pilot Study of Celecoxib and Infusional 5-Fluorouracil as Second-line Treatment for Advanced Pancreatic Carcinoma by Michele Milella; Alain Gelibter; Serena Di Cosimo; Emilio Bria; Enzo Maria Ruggeri; Paolo Carlini; Paola Malaguti; Mario Pellicciotta; Edmondo Terzoli; Francesco Cognetti is a Medicine article available to read on EtoBox.
What is Pilot Study of Celecoxib and Infusional 5-Fluorouracil as Second-line Treatment for Advanced Pancreatic Carcinoma about?
## Abstract ## BACKGROUND Cyclooxygenase‐2 (COX‐2) is up‐regulated frequently and may constitute a promising therapeutic target in patients with pancreatic ductal adenocarcinoma (PDAC). ## METHODS Patients with advanced PDAC who had progressive disease after gemcitabine‐based chemotherapy were eligible for this pilot study. Treatment was comprised of oral celecoxib (400 mg twice daily) and protracted intravenous (i.v.) infusion 5‐fluorouracil (5‐FU) (200 mg/m^2^ per day), both given continuously for a maximum of 9 treatment months, in the absence of disease progression or unacceptable toxicity. Patients were examined weekly for toxicity and were restaged every 6–8 weeks for tumor assessment. ## RESULTS Seventeen patients entered the study. Asymptomatic transaminase elevation was the most common toxicity and reached NCI‐CTC (version 3.0) Grade 3–4 in 4 of 133 treatment weeks. No other hematologic or nonhematologic toxicity > Grade 2 was observed. Four patients discontinued celecoxib due to upper gastrointestinal tract toxicity. Two confirmed partial responses (durations of 23 weeks and 68 weeks, respectively) and 2 patients with stable disease (durations of 10 weeks and 13 weeks, re
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- Author
- Michele Milella; Alain Gelibter; Serena Di Cosimo; Emilio Bria; Enzo Maria Ruggeri; Paolo Carlini; Paola Malaguti; Mario Pellicciotta; Edmondo Terzoli; Francesco Cognetti
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)