Opening book details…
Can I read Astrocytic Cell Adhesion Genes Linked to Schizophrenia Correlate with Synaptic Programs in Neurons on EtoBox?
Astrocytic Cell Adhesion Genes Linked to Schizophrenia Correlate with Synaptic Programs in Neurons by Olli Pietiläinen; Aditi Trehan; Daniel Meyer; Jana Mitchell; Matthew Tegtmeyer; Vera Valakh; Hilena Gebre; Theresa Chen; Emilia Vartiainen; Samouil L. Farhi; Kevin Eggan; Steven A. McCarroll; Ralda Nehme is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Astrocytic Cell Adhesion Genes Linked to Schizophrenia Correlate with Synaptic Programs in Neurons about?
## SUMMARY The maturation of neurons and the development of synapses, although emblematic of neurons, also relies on interactions with astrocytes and other glia. Here, to study the role of glia-neuron interactions, we analyze the transcriptomes of human pluripotent stem cell (hPSC)-derived neurons, from 80 human donors, that were cultured with or without contact with glial cells. We find that the presence of astrocytes enhances synaptic gene-expression programs in neurons when in physical contact with astrocytes. These changes in neurons correlate with increased expression, in the cocultured glia, of genes that encode synaptic cell adhesion molecules. Both the neuronal and astrocyte gene-expression programs are enriched for genes associated with schizophrenia risk. Our results suggest that astrocyte-expressed genes with synaptic functions are associated with stronger expression of synaptic genetic programs in neurons, and they suggest a potential role for astrocyte-neuron interactions in schizophrenia.
Who reads Astrocytic Cell Adhesion Genes Linked to Schizophrenia Correlate with Synaptic Programs in Neurons?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Olli Pietiläinen; Aditi Trehan; Daniel Meyer; Jana Mitchell; Matthew Tegtmeyer; Vera Valakh; Hilena Gebre; Theresa Chen; Emilia Vartiainen; Samouil L. Farhi; Kevin Eggan; Steven A. McCarroll; Ralda Nehme
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)